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In turn, the brain exerts a direct influence on the MGB axis through the efferent fibers of the vague nerve, or indirectly (i.e., by the activation of the HPA axis), denoting the bidirectional interplay occurred in this axis [74]

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Organic acids markers and blood panel are retested at three to six months to confirm that mitochondrial function, nutrient status, and inflammation are trending in the right direction