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For these analyses, samples with fewer than 100 reads were removed in each study, and the remaining samples were rarefied to the lowest read count

Ecotox Environ Safe 61:353360 Plakunov I, Smolarek TA, Fischer DL, Wiley JC Jr, Baird WM (1987) Separation by ion-pair high-performance liquid chromatography of the glucuronide, sulfate and glutathione conjugates formed from benzo(a)pyrene in cell cultures from rodents, fish and humans

And, of course, your lifestyle choices, and to an extent, your genetics, also come into play

It has been reported that hippocampal accumulation of mAPP and A impairs mitochondrial dynamics, biogenesis, synaptic activity, glucose metabolism, and autophagy, leading to neuronal dysfunction [43, 44]

For instance, lower levels may play a role in many conditions that are more likely to develop in elderly people