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A phase 2a trial in patients with trigeminal neuralgia, vixotrigine may provide a potential treatment option, although it did not show a statistically significant advantage

doi: 10.1038/nrendo.2018.24 11 MoranLJKoHMissoMMarshKNoakesMTalbotMet al

Glyoxalases (GLO), comprising of GLO-I, II and III, are involved in the detoxification of reactive -oxoaldehydes to D-lactate and oxalate ( Protein covalent modification by AGEs results in functional impairment and formation of toxic protein inclusions associated with various NGDs It has been understood that post-translational modification of proteins brings about alteration in the native state structural integrity leading to at least 2 consequences (Figure 1)

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Glutathione supplementation may not be appropriate for individuals with specific genetic conditions affecting sulfur metabolism, those on certain chemotherapy regimens, or patients with uncontrolled asthma, as case reports suggest potential bronchial reactivity