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"Effect of non-steroidal anti-inflammatory drugs on glutathione levels in various organs of rat." Agents and Actions, 37, C106C108

MPGES1 primarily catalyzes the GSH dependent isomerization of prostaglandin (PG) H2 to PGE2, but a low GST and GPx activity has also been demonstrated 13

Treatment with inactive, negative control compounds ( 11 and 12 ), structurally related to the active inhibitors 1 - 10 , had minimal effect on the GSH/GSSG in treated worms