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Besides its carcinogenic and nephrotoxic effects, hepatotoxic, teratogenic, neurotoxic, genotoxic, and immunotoxic effects have also been described in animals (Marin-Kuan et al., 2006

J Appl Biochem 5:4352 Hibi T, Nii H, Nakatsu T, Kimura A, Kato H, Hiratake J, Oda J (2004) Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis

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[5] Participants who enroll in RCTs differ from one another in known and unknown ways that can influence study outcomes, and yet cannot be directly controlled