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To further probe the catalytic mechanism of arGSTs, we conducted quantum mechanics/molecular mechanics (QM/MM) calculations based on the ternary complex of GSH, ()-catechin ( 12 ) and Pt GSTF8

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( c ) Metagene plot (mean SEM) of IgG control signal within the scaled gene bodies 20 kb of the 498 downregulated genes (top left) and 498 unaffected control genes (bottom left), for both parental (black) and edited K562 cells (pink)