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9 Controversies in astrocyte-neuron metabolic coupling: the lactate shuttle and alternative viewpoints A significant and ongoing debate in brain energy metabolism centers on the quantitative importance and primary pathway of fuel delivery to activated neurons

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Hou et al., identified HDAC5 is a potential downstream target of KRAS via an iKPC mice model

Mutant KRAS increases the expression of glucose transporter 1 (GLUT1) and rate-limiting glycolytic enzymes, including hexokinases, phosphofructokinase 1 (PFK1), and lactate dehydrogenase A (LDHA), promoting glycolytic activity and increasing lactate production [17, 18]

Accumulating evidence has shown that viruses can regulate multiple steps of autophagy, and vice versa in the host, autophagy may also play a crucial role in the viral lifecycle including infection, replication, and/or secretion 33,34,35,36,37