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More importantly, his research was predicated on a need: TMV was an economically important agricultural problem and practical solutions were required in order to control the disease to ensure continued production of tobacco

Stuart King James I wrote a famous polemic titled A Counterblaste to Tobacco in 1604, in which the king denounced tobacco use as [a] custome lothsome to the eye, hatefull to the Nose, harmefull to the braine, dangerous to the Lungs, and in the blacke stinking fume thereof, neerest resembling the horrible Stigian smoke of the pit that is bottomelesse . [9] That year, an English statute was enacted that placed a heavy protective tariff on tobacco imports

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A cigarette pack is the basic unit of sale and the small box you get it from a store