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After performing in-vitro skin penetration studies by Franz diffusion cell using Porcine ear skin it was observed that about 90% and 80% of -carotene and antioxidants were penetrated in the subcutaneous layer after 12 h post application with 63% of skin retention

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This was demonstrated by a sixty percent reduction in mortality risk when compared to the placebo therefore subsequent trials to determine whether or not CNM-Au8 could provide neuroprotective advantages in ALS and other neuro-degenerative disorders are urgently required ( CNM-Au8, nanocrystals were also tested on patients of relapsing-remitting multiple sclerosis (RRMS), non-active secondary progressive multiple sclerosis (SPMS), or primary progressive multiple sclerosis (PPMS) in an investigator-initiated, open-label, expanded-access study (NCT04081714) for evaluating the safety, pharmacokinetics (PK), and pharmacodynamics

Elevations in Methylmalonic acid indicate a functional deficiency in B12 (20)

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