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Moreover, CAFs are glycolytically active and release metabolic fuels into the TME, thereby feeding adjacent cancer cells and reprogramming cellular metabolism toward OXPHOS [82]

Patients in major metropolitan areas including Los Angeles, New York, Houston, and Miami, where concierge medicine, functional medicine, and sports medicine clinics frequently offer cutting-edge supplements and unapproved therapies, are most likely to be targeted with marketing for these compounds once they become more accessible through regulated channels