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While PD is uncommon before the age of 50, its incidence escalates markedly with advancing age, peaking between 70 and 85 years, afflicting 7 to 10 million individuals worldwide (142, 143)

doi: 10.1096/fj.01-0401rev

[3] Overdose and toxicity [edit] Excessive amounts of valproic acid can result in somnolence, tremor, stupor, respiratory depression, coma, metabolic acidosis, and death

Pirfenidone is well tolerated in a long course of treatment and it can be good choice for supportive treatment of COVID-19 during the infection period or even during recovery period