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Tophi develop in and around the joints leading to joint destruction and chronic (long-term, continuous) joint pain and stiffness

Enzymatic assay of D-glucuronate using uronate dehydrogenase

p62 was found to bind to the NRF2-binding site on KEAP1, thereby competing with NRF2 for KEAP1 binding [84]

[PUBMED Abstract] Ruutu T, Corradini P, Gratwohl A, et al.: Use of intrathecal prophylaxis in allogeneic haematopoietic stem cell transplantation for malignant blood diseases: a survey of the European Group for Blood and Marrow Transplantation (EBMT)