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Although rare, mutations in TFR-2 may be the leading cause of hemochromatosis in the Asia Pacific region where the I238M variant of TFR2 (previously reported as a polymorphism) has an allele frequency of 7% [18,19,20]

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GSH depletion can trigger suicide of the cell by a process known as apoptosis

The greatest risk of primary liver cancer occurs in those with cirrhosis [31, 34, 61], and these individuals should be recommended to undergo routine 6-monthly liver ultrasound for liver cancer surveillance [5, 51, 52, 62]

Its when it balances things out