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Mechanism 1: Glutathione Peroxidase (GPx) - The Thyroid's HO Scavenger The glutathione peroxidase (GPx) enzyme family - particularly GPx1, GPx3, and GPx4 - uses glutathione as its essential substrate to neutralize HO in thyroid cells

doi: 10.1016/j.bbadis.2014.10.016 Summary Keywords sirtuin 1, natural compounds, oxidative stress, human disorders, polyphenols Citation Iside C, Scafuro M, Nebbioso A and Altucci L (2020) SIRT1 Activation by Natural Phytochemicals: An Overview

If you take a traditional capsule or powder, the harsh acids in your stomach often break down the delicate tripeptide before it can reach your small intestine for absorption

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J Biol Chem 2012;287(42):35439-35441

The name comes from melas, the Greek word for black, or cholas, from the word green-ish