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Figure 4 Figure 5 To test whether the reduction kinetics of roGFP2-iL is affected by GRX, roGFP2-iL was fused to the C-terminus of Hs GRX1 and the catalytic efficiency for the reduction of the resulting fusion protein by GSH was compared to free roGFP2-iL in in vitro experiments (Figure 6)

2.2 Negative Regulation of Ferroptosis by p53 In addition to its ferroptosis-promoting effects, p53 represses ferroptosis by inducing cyclin-dependent kinase inhibitor (CDKN1A, encoding p21), Parkinson disease 2 (PARK2) and iPLA2, or by inhibiting dipeptidyl peptidase-4 (DPP4) (Kang et al., 2019) (Figure 2)

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Gordon KB, Langley RG, Gottlieb AB, et al