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The main focus is to provide new strategies and recommendations for interventions targeting these mechanisms, as well as for personalized treatment approaches, combination therapies, and the development of innovative drug therapies

Repurposing existing drugs offers a faster route, but theres a core problem: drugs dont act uniformly across all cells

Protein expression levels were tested with chemiluminescence assay (Thermo Fisher Scientific, Waltham, MA, United States)

Psychological state and blood biochemical parameters were examined after exercise

Alternating phases allows pathways to reset and may help maintain effectiveness over time

Nevertheless, inhibiting tumor angiogenesis and promoting tumor vascular normalization are potential new mechanisms for reversing drug resistance in breast cancer