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For example, while circulating thyroid hormone has been shown to increase longitudinal bone growth indirectly by increasing systemic GH secretion [83], it also has been shown to directly interact with the epiphyseal chondrocytes and initiate terminal differentiation [87,88]

Women suffering from this condition have also been shown to frequently associate certain cardiovascular comorbidities, including obesity, hypertension, atherosclerosis, and vascular disease