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Parag Mallick, chief scientist at Nautilus Biotechnology, says he thinks the field is understanding now more than ever that tau is not a single protein that goes up and down. For example, in a single-molecule study that Mallick and his team posted to bioRxiv, researchers identified at least 130 different tau proteoforms in brain organoids and donor tissue

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However, these thiol reagents are known to react with cysteine 93 of Hb, leading to changes in the oxygen affinity as well as oxidative stability of the protein [4,34]

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