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SOCS2 specifically recognizes the N-terminal domain of SLC7A11 via its src homology 2 (SH2) domain and, using residues L162/C166 in its BOX domain, binds Elongin B/C to form a complex that recruits ubiquitin molecules, facilitating K48-linked polyubiquitination and degradation of SLC7A11

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however, the exorbitant expenses of these pharmaceutical agents may restrict their prolonged usage [84]

Saini et al., 2017)

110 Caution should be exercised when prescribing the KD to T2DM patients on other drug treatments, such as sodium glucose cotransporter 2 (SGLT2) inhibitors and insulin

Seroopidemiology of Helicobacter pylori infection of developing and developed countries