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These FAHFAs can be stored as TAGs (156) and mobilized during cold exposure by PNPLA2 to promote de-novo lipogenesis and FA-esterification in an insulin-independent manner (157), possibly explaining the coupling of lipolysis to lipogenesis in adipocytes (151)

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Hepatic knockdown of GADD45 enhances hepatic lipogenenic gene expression in MCD diet-fed mice To investigate how GADD45 knockdown aggravates hepatic steatosis, we compared the expression of lipogenesis-related genes in the livers of GADD45-knockdown and control mice fed an MCD diet

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Potential effects on methylation pathways and NAD+ metabolism should be considered