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In hepatocytes, the mitochondrial activity includes metabolic pathways and signaling networks, which depend on mitochondrial DNA (mtDNA) integrity, affinity and antioxidant balance, membrane composition, transport of lipoprotein, and metabolic demand and supply [57]

doi: 10.1152/physrev.00018.2022 166 SikalidisA

Glucose transporter type 4, an effector protein of the insulin-resistance pathway, directly correlates with proteins, such as Hydroxyacy1-CoA dehydrogenase 1 and Acyl-coenzyme A oxidase 1, that are involved in the KD-induced pathways

Under normal conditions, TMAO is rapidly removed from the circulation, largely via excretion in the urine [56,57]

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