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It is necessary to explore the relationship of iron with the primary and secondary consequences of TBI

Oxidative stress and inflammation are capable of interfering with the process

Ferroptosis, a form of iron-dependent lipid peroxidation-mediated cell death, was first described in animals and is regulated by GPX4 (Dixon et al., 2012

MCT1 is expressed predominantly in tissues with high oxidative capacity, such as cardiac and skeletal muscle, where it facilitates the uptake of lactate for oxidation and ATP production

Mirmohammadali and Rosenkranz, 2023)