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Interestingly, FGF-2 level persisted to be elevated until 12 weeks of cuprizone exposure, failing to potentiate proliferation of OPC significantly, since both the wt mice and FGF / mice displayed a similar number of OPC (Armstrong et al., in vivo , and may even predominantly promote an inhibitory effect impeding OPC differentiation and remyelination (Armstrong et al., 2000

106 As a result, higher doses are often required to achieve therapeutic efficacy, which may increase the risk of adverse effects

Cell Host Microbe 19:443454

PubMed record Spth-Schwalbe E, Schfer A, Uthgenannt D, Born J, Fehm HL

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