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While the hNET is capable of transporting DA and NE with K M values of 0.67 M and 2.6 M, respectively, the hDAT can transport DA and NE with K M values of 2.54 M and 20 M, respectively 19

Notwithstanding the copious experimental evidence correlating the formation of A with cytotoxic effects that may advance the development of NDDs [6871], the detection of A in cognitively normal individuals presents unresolved questions on the nature and function of A oligomeric assemblies that inevitably increase with the aging process [7277]