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Texture and tone shifts show up at 4 to 8 weeks

There is very limited pharmacokinetic information for poor metabolizers (PM) from these studies

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(ii) For single source drugs and biological products assigned to more than one billing and payment code, CMS will sum the allowed charges from final action claims greater than $0 for all billing and payment codes and divide the summed amount by the number of individuals who use such a drug or biological with allowed charges for these billing and payment codes

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The frequency and duration of treatment are also important considerations