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The generated ROS can cause damage to tissues through various pathways

PF may exert antidepressant activity through a variety of mechanisms, such as preventing the overactivity of the HPA axis, regulating the monoaminergic nervous system, maintaining normal calcium homeostasis and calcium signaling pathway, inhibiting oxidative stress and apoptosis, and regulating the expression of neurotrophic factors in the brain (Figure 6)

[DOI] [PubMed] [Google Scholar] Parisi V, Coppola G, Centofanti M, Oddone F, Angrisani AM, Ziccardi L, Ricci B, Quaranta L, Manni G, 2008a

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Fermentation plays a significant role in modifying the bioactivity of polyphenol-rich plant materials (284, 285)

Murphy EJ, Stephens R, Jurkowitz-Alexander M, Horrocks LA