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This allows predicting the drug efficacy in these various patients and cell line backgrounds and estimating the number of patients needed to be treated before seeing a positive outcome (Number Needed to Treat, NNT)

Expression of these autophagy related proteins positively correlated with increased levels of -synuclein in PBMCs [152], suggesting that this may represent a compensatory response to trigger increased protein degradation

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Pexophagy: molecular mechanisms and implications for health and diseases

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