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Notably, extensive research has highlighted TLR2s pronounced expression in various diseases, including cancers [37, 38], autoimmune diseases [39], cardiovascular disorders [40], etc

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An SD diet exacerbates weight loss, reduces colon length, and increases stool bleeding and diarrhea in models of DSS-induced colitis and in shPsat1 mice (short hairpin RNAs, shRNAs targeting the 2nd gene in the SSP pathway), consistent with worsened disease severity and inflammation 62,114

A.ChaudhariA.GuptaR.VelingkaarN.KondratovR

Inhibition of mTORC1 reduces glucose consumption and lactate production, and downregulates the expression of glycolytic enzymes and glucose transporters