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The pathological increase in ROS production in turn can cause damage to intracellular biomolecules such as enzymes, proteins and lipid molecules (Slater, 1984

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Available at: When B12 levels are reduced, methylation efficiency decreases, leading to: Elevated homocysteine levels: High levels of homocysteine are associated with inflammation and oxidative stress, both of which can harm hair follicles and disrupt the hair growth cycle

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Acute neuroinflammation is associated with elevated metabolites in the tryptophan-kynurenine pathway, nitric oxide pathway, neopterin and major lipids 56