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It may be related to toxicity, oxidative damage, poor nutritional status or nutritional deficiencies, heavy metal or environmental toxicity, systemic disorders, hormonal imbalances, xenobiotic exposure, age-related decline, or obesity

In a hospital-based case control study, Barrea and colleagues also found that high circulating TMAO levels are associated with obesity and the severity of MAFLD (Barrea et al., 2019)

More Information about repurposing drugs for use in the context of cancer in general is available at Life Extensions Drug Repurposing in Cancer protocol