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By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel

It is caused by mutations in the NF1 tumor suppressor gene, which encodes a GTPase activating protein (GAP) that negatively regulates p21-RAS signaling

A study has confirmed that the mitochondrial fission GTPase Drp1 inhibitor, mdivi-1, can be used to inhibit mitochondrial fragmentation in -synuclein rat PD models, reducing neurodegeneration and mitochondrial oxidative stress (177)