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Because it lacks GH receptor agonism and does not elevate IGF-1 meaningfully, concerns about carpal tunnel, fluid retention, and glucose dysregulation that accompany full hGH therapy are less applicable

Additionally, ashwagandhas interaction with GABA receptors in the nervous system provides a calming, sedative effect, improving sleep quality a critical factor for muscle repair, hormonal balance, and mental readiness

10.1371/journal.pone.0152371 145 JinK.SimpkinsJ

Walsh, TJ

Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells

At 12-24h, macrophages clearing apoptotic neutrophils upregulate 15-LOX and utilize EPA/DHA to produce pro-resolving lipoxins, resolvins, and protectins (24-72h) that actively terminate inflammation