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In these species, reactive oxygen species (ROS)comprising radicals (e.g., superoxide (O 2 )) and non-radical derivatives (e.g., hydrogen peroxide (H 2 O 2 ))can engage in complex chemical interactions with other reactive species before interacting with larger biomolecules, such as nucleic acids, proteins, lipids, or carbohydrates [2,10,11] (Figure 1)

However, they are also the major site of reactive oxygen species (ROS) production due to electron leakage during oxidative phosphorylation

Differential expression of follicular fluid cytokines: relationship to subsequent pregnancy in IVF cycles

Four primary pathways have been proposed based on preclinical data

Positively and negatively selected sgRNAs were identified at sgRNA, gene and pathway levels using the MAGeCK RRA algorithm

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