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USA 105 , 68036808 (2008)

In contrast, conventional Val-Cit-containing linkers appear to be resistant to all single protease inhibitors (cathepsin B, L, and K inhibitors are all less than 15%)

Also, variations in protein expression involved in oxidative stress homeostasis were found, including reduced expression of NADPH oxidase and glutathione peroxidase, an increase in catalase and a decrease in protein levels involved in lipogenesis and lipolysis

Together, these findings show that disease-associated loss of ACSM3 facilitates mitochondrial dysfunction via a lauric acid-HNF4a-p38 MAPK axis, suggesting a novel therapeutic vulnerability in systemic metabolic dysfunction

Garcia-Manero, G

Analysis of CYS3 regulator function in Neurospora crassa by modification of leucine zipper dimerization specificity