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By decreasing the reduced form of co-enzyme Q, the mitochondrial production of free radical can be decreased

JAMA Netw Open 4 , e2124669 (2021)

Multi-potent stromal cells with the ability to generate connective tissue lineages

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In xenografts derived from PDCs with high expression of VRK2, the growth of the tumor was markedly suppressed in the group that received combined treatment with APR-017 and IC261, followed by the group that received IC261 treatment, and barely altered in the APR-017 group (Fig