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For instance, chronic doxorubicin (DOX) intervention can also lead to cardiomyocyte aging, suggesting that the aging mechanism shares many irreversible stress factors with the cardiac injury pathway, such as decreased Sirtuins expression, increased p38 mitogen-activated protein kinases (p38MAPK) signaling, and decreased antioxidant enzyme levels represented by MnSOD [21, 22]

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Bergman, M., Varshavsky, L., Gottlieb, H

Ryczkowska, K., Adach, W., Janikowski, K., Banach, M

Prescribers managing this group should plan for a longer washout period when scheduling medication transitions or surgical procedures

Reduced medication strength could delay symptom relief