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This approach revealed key interactions between the receptor's transmembrane and extracellular domains, suggesting that K1-70 inhibits TSHR by binding without activating it, while the stimulatory autoantibody M22 likely induces activation through conformational changes in the hinge region (254)

Los continuos avances en la sntesis de pptidos y en las tecnologas de verificacin analtica han permitido a los investigadores estudiar estos compuestos con una precisin cada vez mayor en condiciones de laboratorio controladas