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This distinction raised the possibility that SIRT3, a key regulator of mitochondrial metabolism, preferentially regulates trained immunity at the HSC level

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17 However, among three important intracellular redox systems such as NADPH/NADP, thioredoxin red /thioredoxin ox and GSH/oxidized glutathione (GSSG), cellular GSH levels are 1000-fold higher than other redox couples

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World J Surg Oncol 54:27 Tokumoto M, Lee J-Y, Shimada A, Tohyama C, Satoh M (2018) Glutathione has a more important role than metallothionein-I/II against inorganic mercury-induced acute renal toxicity