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By contrast, deep-learning-based generative models can now interrogate large chemical-biological datasets to uncover structure-activity relationships, generating novel scaffolds with plausible three-dimensional conformations and tailored engagement of both target and E3 ligase, thereby vastly expanding accessible chemical space [62, 282,283,284,285,286,287]

Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant

In the hyperglycemic state, oxidative stress and impaired antioxidant systems underlie DCM pathogenesis

Like chaperone heat shock proteins (HSP), The molecular mass of HSPs ranges from 10 to 200 KD (kilo Daltons)

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Konorev, et al