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The role and mechanisms of gut microbiota in diabetic nephropathy, diabetic retinopathy and cardiovascular diseases

By inhibiting the TGF-1/Smad pathway, GLPs help maintain the balance between the synthesis and degradation of the extracellular matrix (ECM), thereby suppressing glomerular mesangial cell proliferation and renal fibrosis

Representative drugs such as erastin and its derivatives, sorafenib, and natural compounds (TalaA, 18-glycyrrhetinic acid) have demonstrated antitumor activity in various cancers (e.g., HCC, DLBCL, CRC) by inhibiting the SLC7A11 or VDAC pathway (Li Z