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Description

Among the GLP-1 RAs, evidence of CV benefit is strongest for liraglutide, favorable for semaglutide, and less certain for exenatide

Rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) complex 1, exhibits cardioprotective effects in ferroptotic cells, where mTOR overexpression protects against iron-overload-induced cell death, a process exacerbated by mTOR deficiency (67, 68)

M.Rojas-LariosF.Barrn-HoyosJ

10.1016/j.alit.2023.12.006 139 ShahS

The essential feature of apoptosis is the release of cytochrome c from mitochondrial, regulated by the balance of between pro-apoptotic and antiapoptotic proteins in BCL-2 family, activation of initiator caspases (caspase 8, 9, and 10) and effector caspases (caspase 3, 6 and 7) [75]