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Monthly or even quarterly depot injections of GLP-1 agonists are in development

In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself

Many groups of people need to take B12 supplements, including vegans or vegetarians, older adults, those taking certain medications, and people with gut absorption issues

For most people, high-dose oral or sublingual supplements are effective

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