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In wound-healing research, GHK-Cu has been shown to regulate MMP-2 expression and its tissue inhibitors, TIMP-1 and TIMP-2, in fibroblast cultures, indicating a role in controlling ECM remodeling during tissue repair [4]

Sisson also recommends supplementing with fish oil

Vallv-Juanico et al., 2019)

Zhao Y, Lv J, Zhang H, Xie J, Dai H, Zhang X

Since MTX induces oxidative stress by increasing reactive oxygen species in tissues (Reference Jahovic, Cevik and Sehirli38,Reference Moghadam, Tutunchi and Namvaran-Abbas-Abad40,Reference Olayinka, Ore and Adeyemo43) , the effects of various antioxidant substances against MTX-induced oxidative stress have been investigated (Reference Savran, Cicek and Doguc7,Reference Jahovic, Cevik and Sehirli38,Reference Olayinka, Ore and Adeyemo43Reference Yuksel, Yuksel and Yagmurca45)