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PLOS ONE 9 , e109727 (2014)

Bryan Johnson: When I invest in entrepreneurs for the OS fund, I want to find people who are one, future-literate, two, who are working on one of humanity's most audacious challenges or opportunities, and three, if successful, they would improve the lives of billions of people for generations to come

SAT1 was demonstrated to induce ferroptosis by elevating the expression of arachidonate 15-lipoxygenase (ALOX15)[42]

The copper ion is essential for its activity

The animal literature is unusually consistent, though: nearly every published in vivo study used 5 mg/kg per injection, given three times on alternate days (days 1, 3, and 5, or days 14, 16, and 18 in the pulmonary fibrosis model), with effects tracked over the following three to four weeks

Ishijima M, Ghassemi A, Soltanzadeh P, Tanaka M, Nakhaei K, Park W, Hirota M, Tsukimura N, Ogawa T