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Gubern et al

In NL5901 strain, YFP tagged-human -synuclein is expressed under the body wall muscle-specific promoter, allowing visualization of -synuclein in the body wall muscle

Glucocorticoid-like activity of Escin: A new mechanism for an old drug

337 Additionally, navitoclax (also known as ABT-263) is a drug classified as a Bcl-2 family inhibitor. It specifically inhibits the antiapoptotic proteins Bcl-2, Bcl-xL, and Bcl-w within the Bcl family and induces apoptosis through the activation of caspase signaling pathways

In addition, the development of novel intervention strategies that can distinguish between anti-inflammatory and genotoxic effects (such as intermittent administration and tissue selective delivery systems) is expected to balance efficacy and safety while avoiding systemic toxicity

Notably, SPRTN is unable to process crosslinks on strictly dsDNA or ssDNA substrates