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Both methods are equally safe

Imai H, Hirao F, Sakamoto T, et al

Parathyroid cancer The parathyroids are not part of the thyroid gland at all, but are attached to the gland itself

2008 Jan;65(1):51-9

Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats

In conclusion, the present combined clinical and reverse translational approaches unveiled the essential role of the peripheral -adrenoceptor/renin/Ang/AT 1 receptor system in the development of DPN accompanying T2DM, suggesting the therapeutic usefulness of its inhibition for prevention of DPN development