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A key regulator of mitochondrial biogenesis is peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), which activates nuclear transcription factors NRF1 and NRF2, along with mitochondrial transcription factor A (TFAM)

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Microgliosis in the spinal cord is coordinated by sensory afferent derived injury signals, whereby chemokines, nucleotides, and other pro-inflammatory mediators released from damaged afferent terminals could signal through post-synaptic surface receptors to activate microglia

A lot of patients come to me complaining about their hair thinning, and there are many hormonal causes for hair loss in women, which include being perimenopausal, thyroid dysfunction, and PCOS