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The proportion of treatment-nave patients (71.6% in their study and with all were treatment-experienced in our study), male participants (91.9 and 51.1% in Japan and our study, respectively), in addition to study design, sociodemographic characteristics and differences in ethnicity might contribute to this incongruency of findings Although individuals of Africans origins had the lowest hyperuricemia and gout risk allele frequencies than Asian descent (61), they may respond differently to ART to result in hyperuricemia