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Biomedicines 8 , 284 (2020)

In contrast, PHGDH knockout attenuates tumor growth, reduces TAM infiltration, promotes the phenotypic conversion of M2-like TAMs to an M1-like state, downregulates PD-L1 expression, and consequently enhances antitumor T-cell immunity ( Serine generates multiple pivotal metabolites through the one-carbon metabolic pathway (SGP), regulating the development, proliferation and differentiation of CD8 + T cells, effector T cells and regulatory T cells (Tregs)