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This is generally the better choice for a first cycle

In healthy adults, phase I data showed that 60 g/kg doses increased mean 24-hour GH by 210x and IGF-1 by 0.53x over 28 days, with dose-proportional pharmacokinetics [pubmed.ncbi.nlm.nih.gov]

If standardized peptide formulations can be verified and administered within controlled protocols, these agents may represent a future adjunct to evidence-based perioperative care, particularly in populations undergoing TJA where wound healing, metabolic health, and inflammatory regulation strongly influence outcomes

Sermorelin's advantage is its longer history of clinical use and FDA approval for diagnosing growth hormone deficiency

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Unlike earlier GHRPs such as GHRP-2 and GHRP-6, Ipamorelin was specifically designed to minimize off-target endocrine effects